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It has been observed that single nucleotide polymorphisms (SNP) within a miRNA binding site can cause significant phenotypic changes [ 14].
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Thus, even a single nucleotide polymorphism, not in primer binding sites, can cause reproducible PCR bias.
We predicted that only exon-intron boundaries located on oligonucleotide binding sites can cause assay failure.
Preventing the binding of snRNP U1 (at the donor site) or U2/U5 (at the polypyrimidine moiety and acceptor site) can cause modified splicing, commonly excluding exons from the mature mRNA.
The random natures of this attachment sites can cause some loss of the antigen-binding activity due to the steric hindrance [ 10, 11].
The value of n of BSA at all three studied temperatures is approximately equivalent to 1 as fractional binding sites don't occur and no < 1 binding site can be present suggesting only one binding site for rivaroxaban.
The new binding site can be introduced with a minimum of four amino acid changes.
Each hormone binding site can be divided into an inner and outer binding cavity.
In addition, an individual domain or binding site can mediate binding to more than one protein.
Other than SNPs within miRNA target sites, SNPs outside miRNA binding site can affect miRNA function.
Other studies have shown that the CDA '5 flanking region contains numerous potential transcription factor binding sites that can cause variations in transcription [ 18].
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