Sentence examples for binding site as the from inspiring English sources
For the blocking experiments, mice were co-injected with 330 µg (∼0.5 µmol) of unlabeled c RGDyK), a pentapeptide that binds to αvβ3 and αvβ5 integrins [8], [62] at a similar receptor binding site as the engineered knottin peptides.
Molecular docking studies of the biomimetic ligand predicted that it can occupy the same binding site as the natural coenzyme.
The docking poses of compound H5, as an example of the designed compounds (Figures 6 and 7), showed that isatin scaffold structure is oriented in the binding site as the same as the quinazoline moiety of the DJK_3021_A X-ray structure with displacement of the hydrogen bond acceptor atom in compound H5 from those of the quinazoline ring of the DJK_3021_A.
This mRNA, the 1.0X β-globin CAT-FLAG mRNA, is appropriate for determining if LNA-AUG1 induces mRNA cleavage because this mRNA contains the same LNA-AUG1 binding site as the (CAA)4 CAT-FLAG mRNA.
For 23 of the interactions, the three methods report the same binding site as the highest scoring true-positive hit.
Both CASTp and SiteMap confirmed the accuracy of predicted binding site as the binding site revealed by superimposition located within the largest and highest ranked cavity.
These results implicate the P-TEFb binding site, as well as the flanking flexible sequences, in the function of the AFF4 N-terminal segment.
Here, it functions as trigger for a safeguard mechanism that closes the binding site as soon as the ligand is lost.
The ATP binding site was shown to be distinct from both the substrate binding site as well as the distal site where peptide activators such as bradykinin and dynorphin B-9 bind.
The difference Fo − Fc Fourier map was also used to identify conformational changes of residues in the putrescine binding site as well as the active site.
The characterization of GsuK ligand gating including the mutation of nucleotide binding site as well as the quantification of ligand effect will be pursued in our future studies.
