Sentence examples for binding site are lost from inspiring English sources

By a proteolytic cleavage of the C-terminal part of the native molecule some components of the citrate binding site are lost, as well as a motif responsible for the inhibition by ATP (supplemental Fig. S1).

When its cognate binding site is lost, the gene is reactivated [ 54].

As the low‐affinity binding site is lost in gephyrin‐G375D, we conclude that Gly375 is likely an integral part of this binding site.

Presumably, the integrity of the substrate binding site is lost when these residues are mutated leading to lower affinity for substrate.

Here we defined turnover as a case where a mouse binding site is lost at the corresponding region in human, but compensated by a human-specific site within 10 kb of the location of the lost site in human.

As reported by [ 45] (their Figure six), the first Lef1 binding site is found in all tetrapods that were investigated, whereas the second Lef1 binding site was lost (or never gained) in Xenopus frog.

At a single nucleotide position within the target region, we let the birth rate represent the probability (per year) that a new binding site appears when no binding site is present and death rate represent the probability per year that an existing binding site is lost.

This loss of protein function might disconnect the extra-cellular matrix from the cytoskeleton as these binding sites are lost.

However, in aged human skin dermis, collagen fibril binding sites are lost and mechanical resistance to traction forces is reduced due to fragmentation.

For KRAS in human whole blood (six PA sites, all in the 3′UTR), the most frequent PA site is located directly at the distal end of the known 3′UTR, and consequently no miRNA binding sites are lost.

Papatsenko and Levine (2008) proposed that the dual role is facilitated by adjacently bound Hb molecules masking each other's active sites; in this scenario, we would expect dual regulation to be attenuated as binding sites are lost through mutagenesis.