Sentence examples for binding site are highly from inspiring English sources
However, given the prerequisite of CD4 binding to initiate viral entry, the residues lining the gp120 CD4 binding site are highly conserved.
In the case of calcium ATPase 1 (PDB: 1wpg), the ligand and the binding site are highly hydrophobic (Toyoshima et al., 2004).
The E2 enhancer and the extended CLOCK BMAL1 M34 core binding site are highly conserved in humans, raising the possibility that disruption of CLOCK binding disables PER2 transcription in decidualizing cells.
Throughout the POT family the transport mechanism and peptide binding site are highly conserved, with bacterial counterparts sharing ∼80% identity to human PepT1 and PepT2 within their peptide binding sites (Terada and Inui, 2012; Newstead, 2014).
Superposition (overlapping of Cα atoms) of modeled AGPase SS with their structural homologue in DS3.5 reveals that the spatial position and orientation of substrate and inhibitor binding site are highly conserved and 4(b) and Figures 5(a) and 5(b)) and shows a very low RMSD within the substrate and inhibitor binding site which is evident from Table 7.
A high degree of structural homology showed that the thiamin binding site was highly similar to that of the mouse enzyme, but highly different from the bacterial ones.
The CD4 binding site is highly conserved, but nonetheless not all antibodies targeting the CD4 binding site show broad cross-clade neutralization properties including F105, M12 and M14 for example [15], [28] [32].
While the MCoA binding site is highly conserved, NMTs are striking in their remarkable diversity of peptide substrates.
