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Moreover, the numbers of transcription factors predicted to have an autoregulatory binding site are given.
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The complete sequences of all these binding sites are given in the Supporting Material (Fig. S3).
Positions of STAT1 binding sites are given relative to the start of the first exon of each gene.
ChIP-seq data for FOXM1 and ERK2 binding sites are given as BED files in Additional file 1: Table S1.
The nucleotide sequences with lengths of 95 nt that contain multiple miR-619-5p miR-619-5p miR-619-5pand miR-5096-3p binding sites are given in Figures 3 and 4.
The results of these analyses including positions and sequences of the corresponding binding sites are given in Additional file 3. Altogether, 110 different c-Myc binding sites were found in 94 different promoters, which partly were recognized by different matrices.
The results of this analysis including positions and sequences of the corresponding binding sites are given in Additional file 7. Altogether, 368 putative binding sites were found in 220 different promoters.
M-box sequences are underlined and Ste11 binding sites are given in bold. 1 Motifs were identified in the region 2000 bp upstream of the ATG or in the entire inter-genic region where this is less than 2000 bp 2 Divergently transcribed gene pair 3 Divergently transcribed gene pair 4 Not strictly M-specific.
Accordingly, closely clustered phylogenetically conserved binding sites were given more weight than sites that were less closely clustered.
However, refinement is effective only if the approximate peptide backbone conformation within the receptor-binding site is given.
In its crystal structure, (PDB code: 3GID), where Sarophen A is bound to the human ACC 2, the binding site residues are given as Lys274-Ser278-Arg277-Glu593-Met594-Asn599-Asn679-Trp681-Phe704-Trp706. functiona shofs total coresidueon, CT as a functindexf residue index and the residues between Phe704 Ser715, exhibit non-zero values of CT, obtained by using 3GLK.pdb.
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