Sentence examples for binding site and therefore from inspiring English sources
Homology modeling, based on an X-ray structure of rabbit P450 2C5, suggests that the locations of mutated residues are not close to the substrate binding site and therefore that structural elements outside of this site play roles in changing the catalytic activity.
Seven of the nine different residues bury more than 5 Å2 in the IL-10R binding site and therefore are expected to contribute to the binding of IL-10 to the IL-10R.
Most random mutations will decrease the strength of a transcription factor binding site, and therefore substitutions in the absence of selection will tend to decrease the affinity [ 19, 20].
However, it has been shown that dynactin1 in vertebrates and Drosophila contains an independent Arp1 binding site, and therefore dynactin3 might not be essential for the dynactin complex in all species.
In contrast to the wild type Ls-AChBP structure, W53's indole nitrogen atom is pointing towards the binding site and therefore provides ligands with an opportunity for hydrogen bond formation.
Short fragments may present a substantially different binding site, and therefore have a different binding affinity, than the full-length transcript that is considered when the probe is designed.
Also, by increasing access to the substrate, the xylanase enzymes would have more potential xylan binding sites and therefore be less likely to bind competitively to the cellulose chains.
Deletion experiments do not allow the exact identification of transcription factor binding sites and therefore we mutated one predicted ApiAP2 binding site (at position −825/−818), with the sequence TAGAACA [4].
Together these results point to the importance of the stoichiometric relationships between the three NF-κB/Rel proteins and raise the possibility that different Dorsal/Dif/Relish homo- or hetero-dimers may have distinct binding sites and therefore different targets [30], [31], [32].
One possibility is that these non-canonical protein-DNA interactions could be genuine binding sites and therefore an indication that our understanding of DNA-binding proteins is incomplete.
