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During Rev-RRE assembly, structural changes of the RRE originate from the primary Rev binding site and subsequently propagate along the RNA.
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Nonsynonymous single nucleotide polymorphisms (SNPs) in any of the genes encoding ETC subunits could alter the quality of electron flow or affect CoQ binding sites, and subsequently affect ROS production, aging and longevity.
In general, these triggers change the properties of the binding sites and subsequently have an influence on macrocycle/thread interactions.
By comparing the predictions directly instead of aligning individual binding sites and subsequently scoring clusters in which those sites were found, we introduced different assumptions about the functional relevance of unconserved sites.
For example, recently discovered microRNAs (miRNAs) negatively regulate protein synthesis by targeting mRNA for degradation thereby inhibiting transcription, or by blocking mRNA binding sites and subsequently inhibiting translation (Bartel 2004).
Activated NF-κB comprised three dimers, p65/p65, p65/p50 and p50/p50, that individually bound to DNA-binding sites and subsequently triggered transcriptional activity.
The CpG-dinucleotide content of exon 2 (containing the antigen-binding sites and subsequently a high degree of polymorphism) was much elevated as compared to the other exons despite similar overall G+C content.
For the z-score statistics we referred to a standard statistical method for the annotation of TF hits (Rahmann et al., 2003), which balances the expected number of true and false positive binding site predictions and subsequently applied a z-score statistics [as used for instance by oPOSSUM (Ho Sui et al., 2007)] to detect any binding site enrichment in a given tissue category.
This final set of high confidence peaks was subsequently used in further transcription factor binding site and Gene Ontology analysis.
NS3h contains two important binding sites: the NTPase binding site and the RNA binding site.
(D) Comparison between adamantane binding site and HMA binding site of HCV p7 channels.
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