Sentence examples for binding site and can from inspiring English sources

Allosteric modulators bind to regions that are distinct to the orthosteric binding site and can alter agonist sensitivity, agonist efficacy and channel kinetics.

This approach yields details of the energy contours around the binding site and can be used to characterize and predict good binding sites.

Although CD4-independent viruses are well described for HIV and SIV, these viruses characteristically retain their CD4 binding site and can engage CD4 if available.

Thus, the PIK3CA promoter contains a functional NF-κB binding site and can be activated by NF-κB NF-κB

Eukaryotic Hsp90 functions as a homodimer with each monomer comprising of an N-terminal ATP-binding domain that is responsible for the ATPase activity of Hsp90, a middle domain that harbors the client protein binding site and can also regulate the ATPase activity of the N-terminal domain, and a C-terminal dimerization domain [4].

Two hydrophobic pockets are located close to the benzimidazole moiety in the canonical binding site, and can be explored for compound optimisation.

The affinity profiles of our fragment screening studies furthermore match the chemical properties of the H4R and 5-HT3AR binding sites and can be used to define molecular interaction fingerprints to guide the in silico prediction of protein-ligand interactions and structure.

Combinatorial control is a general term that describes cases in which multiple TFs regulate a promoter, using either the same or multiple binding sites, and can also encompass protein protein interactions in which the same cofactors are recruited by multiple TFs.

The present structures provide explanation for ligand binding, refine the purine-binding site, and can be used for future inhibitor design.

Analysis of the structural differences among the HsPNP Gua complex, PNP apoenzyme, and HsPNP:immucillin-H provides explanation for inhibitor binding, refines the purine-binding site, and can be used for future inhibitor design.

Analysis of the structural differences among the HsPNP Acy complex, PNP apoenzyme, and HsPNP Immucillin-H provides explanation for inHsPNP Immucillin-Hefines the providesinding sitexplanationbe used for future inhibitor design.