Sentence examples for binding site and an from inspiring English sources
Therefore, mutating Phe 27 to a significantly smaller side chain could possibly result in easier access to the binding site and an increase in transport rate.
We also provide molecular evidence for the plasticity of the TAS2R16 binding site and an explanation for the relatively broad specificity of the receptor.
Molecular docking is a computational technique that can be used to model the interaction between a small molecule and a target protein at the atomic level, subsequently providing the prediction of which conformation best fits the protein binding site and an estimate of the stability of the ligand protein complexes [64].
Transducer of Cdc42-dependent actin assembly (Toca-1) consists of an F-BAR domain, a Cdc42 binding site and an SH3 domain.
Overlapping peptide fragments from c-terminal filamin A revealed filamin A2561-2565 as the binding site, and an alanine scan of this pentapeptide revealed an essential mid-point lysine.
As members of family C of the G-protein coupled receptors, group I mGluRs possess a large extracellular domain containing an orthosteric binding site for glutamate, a heptahelical transmembrane domain that contains an allosteric modulatory binding site, and an intracellular C-terminus that interacts with anchoring/scaffolding proteins and controls the constitutive activity of the mGluR [12] [13].
What's more, the ATP-binding site and A-loop motif had been identified to play key roles in TYK2-targeted inhibitor discovery.
A direct correspondence between this nucleotide binding site and a site on soluble CF1 that hydrolyzes ATP was demonstrated.
PFCs have the same binding site and a similar affinity to serum albumin as fatty acids [80].
A second, PP-1bp80, identified in the EST data bases, contained a putative PP-1C binding site and a nucleotide binding motif.
