Sentence examples for binding site and affinity from inspiring English sources

Also, ginsenoside-Rd did not change binding site and affinity of [3H]-prazosin for α1-adrenoceptor in the vascular plasma membrane.

Therefore, we characterized the binding site and affinity of the MUC1-CD for Src-SH3 using multidimensional nuclear magnetic resonance (NMR) spectroscopy to monitor the titration of the 15N labeled Src-SH3 domain with synthetic native and mutant peptides of MUC1-CD.

We used multiple in vitro binding experiments to test binding site and affinity for two top hits from iDTP, namely the peroxisome proliferator-activated receptor gamma (PPARγ) and B-cell lymphoma 2 (Bcl-2).

Antibody offers the potential to select binding site and affinity to optimise therapeutic neutralisation – this in turn may offer advantages midst the complex milieu of regulatory pathways described for IL-18.

Remarkably, the well-folded protein is significantly shielded from anion binding in terms of the number of binding sites and affinity.

Predicting DNA binding sites and affinities from transcription factor sequence or structure is difficult; therefore, experimental data are required to link transcription factors to target sequences.

8 More recently, Schymkowitz et al 9 have published Fold-X, a method and empirical force field developed for, amongst other things, the fast prediction of the binding sites and affinities of metal ions, including Ca2+ and its rival Mg2+.

The complex multi-component decay kinetics of each trace reflects the multiple Ca2+ binding sites and affinities of the two lobes of CaM for Ca2+ (Faas et al., 2011; Faas and Mody, 2012).

Developments in NMR screening, including the use of cryogenically cooled NMR probes and 19F-containing reporter molecules have expanded the scope of this technique, while increasing the availability of binding site and quantitative affinity data for the fragments.

The chain length and the functional group of the PFCs have an influence on the preferential binding site and binding affinity [80].

A standard rigid-flexible AutoDock Vina technique produced two main results: a particular conformational sampling as a docking pose of the ligand molecule within the binding site, and an affinity (ΔG) describing the receptor ligand interaction strength.