Additionally, the phosphate binding loop forms the ceiling of the ATP binding site and clamps down over the phosphate groups to orient them for catalysis.
NS3h contains two important binding sites: the NTPase binding site and the RNA binding site.
(D) Comparison between adamantane binding site and HMA binding site of HCV p7 channels.
Additionally, substantially more statistical testing would be needed in order to rule out the possibility of chance matches in the binding site, and to show a specific association between transcripts containing the binding site and transcripts that are upregulated.
Additionally, compared to all other AdoMetDC structures, there is a conformational change in residues Glu11, Lys80, Ser229, and His243 in E256Q +Put), which link the putrescine binding site and the active site.
The protein functional sites consist of various types of binding site including protein-ligand binding site, protein-protein binding site, and protein-DNA binding site.
We also analysed all promoters for putative AtfA binding sites and revised the Results section accordingly: "Therefore, we additionally searched for putative palindromic AtfA/Sko1-binding sites (5′-TKACGTMA-3′) in the promoter regions of the cluster (Proft et al., 2005).
Additionally, Gene Set Enrichment Analysis found strong correlation between HIF binding sites and up-regulation of genes, whilst there was no correlation between down-regulated genes [ 33].
Additionally, we show the functional importance of the spacing between the two FUSHI-TARAZU binding sites and discuss the potential importance of cooperativity for transcriptional activation.
The binding mechanism, binding constants, binding sites and binding distance were obtained.
