The most significant motif corresponds to the known Zelda binding motif (significance = 35.54 in purely zygotic genes), detected in upstream regions of the zygotic clusters and in the first introns of the maternal+zygotic cluster.
Expectation values of 0.1 and 0.01 were used as the control for binding site significance.
In the light of this and our observation that XRCC1 Ser525 and XRCC4 Ser237 make no significant contributions to APLF or aprataxin FHA domain binding, the physiological significance of these two peripheral sites remains unclear.
The 145-page manuscript had been in Alnwick since at least 1872, disguised in a much later red Morocco leather binding, and its significance was only spotted when it was included in a large sale from the Duke of Northumberland's ancestral collection at Sotheby's last summer.
These results highlight the limitations of current bioinformatic prediction algorithms for identifying miRNA-mRNA binding of potential significance [37], [38].
As with CD36 binding, the pathophysiological significance of ICAM1 binding is unclear.
Eid et al (2000) reported MRP1 expression in the nucleus, in accordance with our observation, an intriguing binding of unclear significance.
Hepatitis C virus (HCV -binding protein enricHCV -bindingicance levels: * for protein1 and *** for p < 0.0001.
Functional categorization of genes in the severely attenuated mutants revealed significant enrichment for RNA binding proteins, suggesting the significance of post-transcriptional gene regulation in parasite development and emphasizing its importance as an antimalarial target.
By associating a P-value with the ratio, we can satisfactorily determine smaller, significant sets of predicted disrupted TF binding sites and provide significance scores of results across a large number of SNPs.
