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Because cofilin binding depends strongly on the actin-bound nucleotide, direct visualization of fluorescent cofilin binding serves as a marker of the actin filament nucleotide state during assembly.
This conformational equilibrium, which is cooperative, reversible, and controllable by ligand binding, serves as a model for the coupled binding and folding mechanism widely used to mediate protein protein interactions and cellular signaling processes.
The document that emerged from the Rio+20 conference, while not legally binding, serves as a roadmap for sustainable development.
This transphosphorylation of PDGFR upon ligand binding serves two important purposes.
Protein binding serves to globally shorten the T1 values and make them more uniform.
This binding serves to retain the dimers in the cytoplasm, which are hence unable to initiate transcription of target genes.
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This indicates that deformations upon binding serve as a conformational proofreading mechanism, which may be selected for via evolution.
Furthermore, expression of Anxa6S13E, a mutant dominant negative with respect to Parp1 binding, served as an enhancer of mitochondrial dynamics, even under chronic PE treatment.
The R2 and R3 MYB repeats of the B. vulgaris R2R3-MYB family contained characteristic amino acids, including the most prominent series of regularly spaced and highly conserved tryptophan (W) residues, which are known to play a key role in sequence-specific DNA binding, serving as landmarks of plant MYB proteins.
This binding affinity serves as one molecular metric of immunogenicity.
The transposed ligand binding pose serves as the starting structure in the following docking and scoring.
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