Because cofilin binding depends strongly on the actin-bound nucleotide, direct visualization of fluorescent cofilin binding serves as a marker of the actin filament nucleotide state during assembly.
This conformational equilibrium, which is cooperative, reversible, and controllable by ligand binding, serves as a model for the coupled binding and folding mechanism widely used to mediate protein protein interactions and cellular signaling processes.
The document that emerged from the Rio+20 conference, while not legally binding, serves as a roadmap for sustainable development.
Protein binding serves to globally shorten the T1 values and make them more uniform.
This transphosphorylation of PDGFR upon ligand binding serves two important purposes.
This binding serves to retain the dimers in the cytoplasm, which are hence unable to initiate transcription of target genes.
Furthermore, expression of Anxa6S13E, a mutant dominant negative with respect to Parp1 binding, served as an enhancer of mitochondrial dynamics, even under chronic PE treatment.
Therefore, IGF-1 receptor binding serves as an extracellular signal to stimulate its intracellular substrate IRS, which leads to activation of PI3-kinase.
32 Insulin detemir is thereby retained in the injection depot and, once absorbed, further albumin binding serves to retard it in the circulation and buffer the effect of any sudden changes in absorption rate.
The R2 and R3 MYB repeats of the B. vulgaris R2R3-MYB family contained characteristic amino acids, including the most prominent series of regularly spaced and highly conserved tryptophan (W) residues, which are known to play a key role in sequence-specific DNA binding, serving as landmarks of plant MYB proteins.
