Three AON sequences were designed to sterically block the putative binding sequences for splicing factors necessary for exon recognition.
This region also contains an inverted repeat sequence, which is the binding sequence for TraJ.
(C ) Amino acid sequence alignment of the site 1 binding sequences in various partners showing the similar sequence pattern, with the anchoring Glu boxed.
Many binding sequences related to various functions occurred at low frequency and were not significant.
Such mutations can affect, for instance, the Shine-Dalgarno ribosome-binding sequences of the various cistrons within an operon or affect the coding sequences themselves by, for instance, changing a preferential codon to a non-preferred one [ 31].
Within the fourth intron there is a sequence of 160 base pairs enriched in binding sites for various transcription factors important in hematopoiesis, suggesting that this element might act as a regulatory enhancer.
In addition to coding regions, Helitrons have mediated massive movement of a diverse collection of host sequences, including promoters, poly-A addition sites and binding sites for various regulatory proteins across the genome.
Sequence analysis has revealed that the hTERT promoter is GC-rich, lacks TATA and CAAT boxes, and contains binding sites for various transcription factors, including c-Myc, AP-1 and E2F and the tumor suppressors WT1 and p53.
Experimental approaches to locating binding sites on DNA [ 7, 8], have uncovered numerous binding sites for various factors.
However, isoform-specific differences exist in terms of binding affinity for various ligands [ 3].
