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Further, functional transcription factor binding sequences are also nucleosome-free regions [ 17].
However, many of their binding sequences are also distinct (the TF spheres appear not to overlap completely).
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The high degree of homology between the two RNA-binding motifs of Drosophila TBPH and human TDP-43 and the finding that they can functionally substitute for each other (Feiguin et al. 2009; Lu et al. 2009; Li et al. 2010) suggest that the target binding sequence is also conserved.
The extended consensus AP-1 (cJUN -binding sequencJUN -bindingown.
The canonically structured, KAP1-binding repressiversioniof of the KRAB A domain is dominant only in mammals, although a similar (and possibly still KAP1-binding) sequence is also the dominant version of the ZNF-linked KRAB A domain in birds.
Single base substitutions to the higher vertebrate Su(h) binding motif found in fish sequences are also underlined.
Several Smad-binding consensus sequences were also detected (data not shown), indicating the potential involvement of alternative non-myogenic regulatory elements.
Thus it seems that, as far as these TEs binding sequences are concerned, a twofold picture exists also for the network rewiring.
G-tracts were potentially associated with these TBP and SNAP50-binding regions, although similar sequences were also found in other regions of the genome.
The positions of AGO2 binding sites in relative to L1 sequences were also calculated.
In SecY the binding pocket of N-terminal signal sequences is also universally conserved and is situated in the lumen of the channel [ 15] (Fig. 1).
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