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The more stringent the prerequisites of the interaction, the longer is the random binding sequence that is to be matched.
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Binding was specific, as these complexes were displaced by a 100-fold excess of cold oligonucleotide containing the Oct-4-binding site, but not by a 100-fold excess of cold mutant oligonucleotide containing a mutant Oct-4-binding sequence that is not recognised by Oct-4 (data not shown).
There is modest overlap in the predicted transcription factors for the three genes, but no binding sequences that are conserved between Ppargc1a and Ppargc1b but not Pprc (Figure S1a).
Furthermore, cis-regulatory element analysis of co-regulated genes between RHs and PTs revealed conserved binding sequences that are likely required for the expression of genes comprising the apical signature.
The activated p53 binds to its DNA-binding consensus sequence that is present in its target genes [15].
In contrast to rodents, the dog-specific expansion appears more limited, resulting in well under a thousand binding events and a sequence that is centered solely on the M1 motif.
STC protein contains seven copies of a cysteine-rich motif that determines binding specificity to conserved X-box sequence that is present in a variety of eukaryotic genes.
The reason for this is that the consensus sequence that is the binding site for the runt family of transcription factors is the same for all three members, so the artificial use of oligonucleotides or even co-transfection does not fully resolve the issue.
A third element of DNA involved in the regulatory loop of an operon was a binding site, or signal sequence that was not transcribed at all.
Let denote the number of (unknown) binding sites and the (hidden) start positions of nonoverlapping binding sites in sequence ; that is, if then.
One mechanism rests on binding sites in their messenger RNA sequence that are recognized by smaller RNA molecules called microRNAs.
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