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The location of the binding sequence is shown as a shaded region.
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Additionally, NF- κB induced the expression of HB-EGF, and the NF- κB and SP1 binding sequence was shown to be the same GC-rich element in colon cancer cells 16, 28.
While DevRC interaction with DNA oligonucleotides containing two consensus binding sequences was shown by crystal structure analysis [18], phosphorylation of intact DevR at Asp54 was found to be essential for interaction with DNA [20].
The previously reported ScbR binding consensus sequence is shown aligned with the consensus sequence found for network module 544 (also shown) in Figure 6.
A Nox5 ortholog (# 45) of zebrafish Danio rerio (D. rerio) also did not contain the presumed start codon and the calcium-binding domain (sequence is shown in Additional file 4), suggesting that the sequence of this Nox5 ortholog is also incomplete.
(A ) Position of the putative CaM-binding site in UNC-13L and its alignment with the rat Munc13-1 CaM-binding sequenceuence are shown.
For each target gene, translation/transcription start sites, promoter -10 and -35 elements, PhoP-binding sites, and PhoP box sequence were shown together.
Originally, the binding of CaM to its target sequence was shown to involve the collapse of CaM around the peptide [2] [4]; the idea was proven by studies on peptides from CaM-dependent protein kinases (CaMKs) as well as from other proteins [5], [6].
The reported LC sequence was shown to be both essential and sufficient for formation of RNA granules through trapping of RNA binding protein-containing LC sequences, including FMRP.
In conjunction with these findings, consensus heparin-binding peptide sequences were shown to be antibacterial[16] and specifically interact with membranes[17].
These two peptides were designated as INr-1 and INr-2 and their binding pattern and amino acids sequences are shown Fig 1A and Table 1 respectively.
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