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Its DNA binding sequence is conserved between C. albicans and S. cerevisiae and is in a region of the ERG11 promoter critical for azole induction of ERG11 expression [ 46, 47].
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FOXO1A was also found among the positively selected genomic regions in Thoroughbred and its PDK4 promoter binding site sequence is conserved in horse.
The high degree of homology between the two RNA-binding motifs of Drosophila TBPH and human TDP-43 and the finding that they can functionally substitute for each other (Feiguin et al. 2009; Lu et al. 2009; Li et al. 2010) suggest that the target binding sequence is also conserved.
On the right edge of receptor-binding pocket, AA sequences were conserved and no substitution was found in this study.
The core binding sequence HFRW is conserved between human and sea lamprey melanocortin peptides but α-MSH and ACTH (not β-, γ- or δ-MSH) have much larger conserved motif SYSMEHFRWGKP in all species described so far, except the gecko Eublepharis macularius, [ 25].
HA sequences were conserved at the receptor-binding site.
These long disordered binding sequences are typically conserved, so they often show up in databases derived from hidden Markov models such as Pfam or SMART (Chen et al., 2006a, b).
There is modest overlap in the predicted transcription factors for the three genes, but no binding sequences that are conserved between Ppargc1a and Ppargc1b but not Pprc (Figure S1a).
The EuphMLSUF primer binding site is conserved in the euphausiid genera we were targeting and is not conserved in sequences available from non-euphausiid crustaceans (Table S1).
The Sm-binding sequence AATTTTGG was conserved in SLG1, SLG2 and SLG3.
Not surprisingly, it is almost only the homeodomain, which serves as sequence-specific DNA binding motif that is conserved amongst different species [ 46].
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