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The bioinformatic database PicTar (http://pictar.mdc-berlin.de/) predicts miR-155 targets human PKIα and the core binding sequence has a 7-mer match in the 3'UTR (Fig. 7B).
The binding sequence has a nearly 100% identity to the weighted matrix consensus sequence (Swirnoff and Milbrandt, 1995) (http://www.cbil.upenn.edu/cgi-bin/tess/tess?request=IMD-DBRTRV-Accno&key=I00117), indicating that it is a high-affinity site for Egr-1 binding.
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We find that TF pairs with similar binding sequences have a lower average profile distance (0.17 vs 0.35, p-value of 7*10-5 7*10-5
A Notch binding sequence has been reported within the HER2 promoter and suggests a mechanism for Notch/HER2 cross-talk [ 33].
A consensus DNA binding sequence has been identified but does not fully explain every gene regulated by Vfr [14].
A consensus DosR binding sequence has been identified in the upstream regions of many genes from the DosR regulon [22], [25].
PRDM5 acts as a sequence specific DNA-binding transcription factor, and its consensus DNA binding sequence has recently been described [15].
The predicted binding sequence has been hyper linked into database).
In E. coli, the consensus ArcA-P binding sequence has been concluded computationally on the basis of DNA footprinting data [ 12].
Interestingly, although interaction partners and their binding sequence have been revealed only a few direct target genes of BCL11B have been discovered to date.
Comparison of Pum1-associated mRNAs to mRNA targets of PUF proteins from Saccharomyces cerevisiae and Drosophila melanogaster demonstrates how a well-conserved RNA-binding domain and cognate binding sequence have been evolutionarily rewired to regulate the collective expression of different sets of functionally related genes.
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