Sentence examples for binding selectivity of the from inspiring English sources

Histone binding selectivity of the yeast BRDs was assayed by a dot blot assay.

Because the site-specific lysine acetylation in histones, and the N- or C-terminal sequences of histones are conserved between yeast and human, we reasoned that knowledge of histone binding selectivity of the yeast BRDs can help understand the ligand binding selectivity of the human BRDs.

However, given that our study of yBRDs' histone binding was done under the same conditions, our results lay an important foundation to elucidate the molecular basis of hisone binding selectivity of the yeast BRDs.

While histone lysine acetylation plays a crucial role in regulation of chromatin-mediated gene transcription, a high degree of sequence variation of the acetyl-lysine binding site in the bromodomains has limited our understanding of histone binding selectivity of the bromodomain family.

To further elucidate mainly the binding selectivity of the best possible candidate suggested from binding assays, 20 ns explicit water MD simulations were conducted [ 38].

28 The corresponding residue to Leu190 in drd2 is an asparagine (Asn186), whereas the Ser188 in drd1 corresponds to Ile184, which may reflect the D1/D2 binding selectivity of the aza analogues.

The binding energy of coordination reaction was used to evaluate the metal binding selectivity of these macrocycles.

Clearly, the number of nitrogens plays an important role in the metal binding selectivity of these systems.

In this study, we investigate the main forces that determine the binding selectivity of DB18C6 for the metal cations in aqueous solution using the density functional theory (DFT) and the conductor-like polarizable continuum model (CPCM).

We also examined the binding selectivities of these proteins toward SGTP and GTP, which allowed for the revelation of the relative binding affinities of the two nucleotides toward the nucleotide-binding motif sequence of proteins.

Comparing the theoretical binding selectivity of DB18C6 with the experimental one, we verify the feasibility of calculations using the continuum solvation model in predicting the binding selectivity of crown ethers.