Sentence examples for binding selectivity of peptides from inspiring English sources

We sought to improve the Mcl-1 binding selectivity of peptides identified in screening using rational mutagenesis guided by prior studies.

Receptor binding selectivity of radioligand candidate compounds.

Histone binding selectivity of the yeast BRDs was assayed by a dot blot assay.

RanBP3 alters the cargo-binding selectivity of CRM1, favouring the binding of NES-bearing peptides over that of Spn1 [23].

Therapeutic index was used to evaluate the selectivity of peptides against prokaryotic cells.

Structural studies elucidate the mechanism governing the Atg8 binding potency and selectivity of the peptides, reveal a general Atg8-binding sequence motif, and allow development of a more GABARAP-selective inhibitory peptide.

To harness the robust binding affinity and selectivity of structured peptides for interactome discovery, we engineered photoreactive stapled BH3 peptide helices that covalently capture their physiologic BCL-2 family targets.

However, the selectivity of peptide and subsequent specificity of nanoparticle targeting are still under investigation.

Therefore, it is conceivable that a detailed understanding of the molecular basis of the histone binding selectivity would require additional structural analysis of BRDs bound to different peptides derived from their biological binding partners.

In this study, we tested the differential binding selectivity hypothesis by investigating interactions of arsenite, ATO, and MMA III) with three different configurations of zinc finger peptides and proteins: C2H2 (aprataxin, APTX), C3H1 (PARP-1), and C4 (XPA).

Finally, assays of eight Bak peptide analogues on Bcl-2 allowed us to postulate that modulations at position 78 could afford peptides with a binding selectivity enhanced for Bcl-xL.