Sentence examples for binding selectivity in a from inspiring English sources
Anion-induced conformational switching provides insight into binding selectivity in a series of heteroaryl-urea receptors.
In this work, it is demonstrated that by using a library of N-alkylated aromatic oligoamide helix mimetics, potent helix mimetics which reproduce their biophysical binding selectivity in a cellular context can be identified.
Thus the results establish that these helix mimetics can reproduce their binding selectivity in cells, whilst dual inhibition of hDM2 and Mcl-1 may also represent a novel approach for elaboration of anticancer chemotherapeutics.
AAL-2, although newly discovered, has the potential to be utilized as a molecular probe to detect terminal GlcNAc sugars with high binding selectivity in glycan analysis.
However, the terminal substituents were found to hardly affect the binding selectivity in the studied cases.
First, analysis of in vivo binding is necessary to understand Hox target specificity; the Hox genes encode a set of closely related DNA-binding transcription factors that exhibit clear functional specificity in vivo but show little binding selectivity in vitro (reviewed in [5]).
It is important to point out that it is likely such optical titrations are notably less reflective of binding selectivity in that they report anion association, be it cavity confined or peripheral.
Of these, (3R -7-hydroxy-N- 1S -2-methyl-[4-methyl-4-pyridine-3-yl-carboxamide (3R -7-hydroxy-N- 1S -2-methyl-[4-methyl-4-pyridine-3-yl-carboxamideGTPγS functional assay, with a Ke = 0.18 nM at the KOR and 273R -7-hydroxy-N- 1S -2-methyl-[4-methyl-4-pyridine-3-yl-carboxamideDOR, respectively.
Since the genomes encode high numbers of other promiscuous interaction domains, we suggest that their binding selectivity may be regulated in a similar multidimensional way.
Those indicate that the solvation free energy of M+-DB18C6 plays a critical role in determining the binding selectivity of DB18C6 in aqueous solution.
This study shows that the implicit solvation model like the CPCM works reasonably well in predicting the binding selectivity of DB18C6 in aqueous solution.
