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Therefore, all GA-sequences should, their overall individuality [1] notwithstanding, contain or be flanked by a common binding segment for these universal linker molecules.
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The basic binding segment for PEG was found to be close to an averaged molecular weight of ∼4000 Da.
3) "Loop swap" experiments show that the loop between β1 and β2 of the Bub3 binding segment accounts for at least some of the differential properties of the two paralogs.
(Is this result completely new, or are there published experiments that come to the same conclusion?) 3) "Loop swap" experiments show that the loop between β1 and β2 of the Bub3 binding segment accounts for at least some of the differential properties of the two paralogs.
These results reveal that the binding behavior of different organisms varies within the binding segments also for protein-RNA complexes and the observation was found to be statistically significant (p = 0.0347).
†A, toxic gene tcdA; B, tcdB; cdtB, CDTb gene for the binding segment of the binary toxin; – and + indicate absence or presence of the gene.
For example, a 4-residue binding segment has a stretch of four consecutive binding residues.
For the binding of DA, Tyrosine (Tyr10) was identified as the strong binding site, and serine-asparagine-lysing (SNK 26 28)) segment was the weak binding segment.
Twenty five of these residues lie in the substrate binding segments, and another 38 lie outside of these areas.
In the "cis" model the N-terminal DID-DD region directly occludes the actin binding surface of the FH2 dimer while in the "trans" model the DID-DD region is maintained at a distance from the surface of the FH2 domain by the long αT helix, which extends from the FH2 domain to present the DAD segment for binding.
Various factors may influence the stability of large var gene segments across a parasite population, including malaria endemicity, the frequency of mixed infections, or functional selection on that gene segment for binding.
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