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As 88% of identified direct target promoters were specific for TEL-AML1 as compared with TEL and AML1 ChIP in this study and very recent AML1 ChIP-seq results, other determinants of binding seem to be involved.
Thus, while a change in the kinetic of GTPγS binding is a good measure of activation of physically coupled G-protein/β2- adrenoceptors, kinetics of GDP binding seem to be a closer measure in case of M2 muscarinic receptors and likely in other GPCR.
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However he thought that "the binding seems to be of the time of Queen Elizabeth"!
Their binding seems to be dependent on histone H3K4 methylation and they likely establish lineage-specific transcription [41].
As binding seemed to be a prerequisite for killing, we searched for YadA-binding substrates and detected the presence of collagen within NETs.
The same situation is observed at a few other promoters but for the most part, their binding seems to be independent.
Strong aglycone binding seems to be important for transglycosylation with saccharides.
Further, receptor binding seemed to be induced or enhanced by oxidative modifications, aggregation or degradation.
Enrichment of FOXA1 binding seems to be most evident around intergenic ERE's, and almost undetectable at promoters [ 16].
(51) For all the cases, the binding seems to be driven by decreases in the surface exposed to the aqueous environment.
Importantly, this 'anticipatory binding' seems to be specific for the signal peptides of membrane proteins, which are slightly longer than the signal peptides of secreted proteins.
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