Sentence examples for binding resulting in a from inspiring English sources
It was shown in earlier work that smaller particles are not desirable, for they require more polymers for effective binding, resulting in a lower flexural strength.
Introduction of the metal chelate had only a minimal effect on receptor binding resulting in a slightly lower affinity of [natGa]3 compared to peptide 2. Corresponding inhibition curves are given in Fig. 1.
As a first approximation, interactions presented in the native state (native interactions) dominate in processes such as protein folding and binding, resulting in a funnel-like energy landscape with minimal frustration [1] [3].
We then engineered a more potent non-IGFBP-3 binding analogue of HN, with two substitutions, S14G (HNG, an analog shown to be more potent), along with F6A (resulting in non-IGFBP3 binding) resulting in a more potent, non-IGFBP-3-binding analogue of HN, termed HNGF6A.
FdUMP potently inhibits thymidylate synthetase by competitive binding, resulting in a thymine-depleted state ('thymine-less death').
This would be likely to disrupt substrate and cofactor binding resulting in a lack of oestrogen synthesis.
However, the gltA1 (A258T) mutation greatly diminished NADH binding, resulting in an inability to saturate the enzyme within the range of detection in the binding assay, which extends up to ∼10 μM NADH (Dickinson, 1970).
Small structural differences has previously been observed in X-ray crystal structures of Ek/peptide complexes where substitution of an MHC anchor residue with maintained MHC binding resulted in a 1000-fold decreased T-cell response [74].
For 9B6, also a non-blocking mAb, mature B cells ranged from 25 35%, whereas treatment with either 9B9 or 5H10 mAb, both of which blocked BAFF binding, resulted in a dramatic decrease of up to 80 90% of circulating B cells (figure 2A).
As detected by western blotting, monobody binding resulted in a modest reduction in activation loop (Tyr412) phosphorylation of Bcr-Abl.
