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The peptides modified at the histidine positions showed nearly a two fold enhanced binding response compared to that of native human Aβ40 or rodent Aβ40 (Aβ40 R5G, Y10F, H13R) (Figure 4B).
The three V2 residues that conferred the strongest binding to CH58-UA when mutated to Ala were Leu179 (a ~ 6.1-fold increase in the SPR binding response compared to wild-type peptide), Ile181 (a ~ 3.9-fold increase in the same), and Val182 (a ~ 3.4-fold increase in the same).
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We observed that the S32 variant of each SOD1 mutant displayed significantly lower ThT binding responses compared to their W32 counterparts, consistent with decreased fibrillation propensities for the S32 variants (Fig. 1A).
We found that infectious gastroenteritis produced a higher signal response compared to controls, due to binding of HGF to monoclonal anti-HGF antibody as well as binding of HGF to c-Met receptor (p < 0.01).
How do the students' responses compare to the responses of those polled by The New York Times?
However, this strategy was found to have limitations in eliciting antibody response as compared to covalent binding of the protein to the liposome [ 90].
Removal of the C-terminus distal of HBD-3 (Vn80–373) had no significant effect on binding when compared to Vn80 396.
The high amylose starches showed relatively weak binding as compared to the normal starches having approximately 25% amylose.
KatA1 49 did not show any binding to Vn and, accordingly, KatA51 505 was not impaired in binding Vn when compared to the full-length protein (Fig. 5b).
Our experimental results demonstrated proof-of-concept flow-through biosensing and a sixfold improvement in sensor response time compared to the conventional closed-ended, flow-over PSi sensor when monitoring the streptavidin-biotin binding process [43].
LZ modification greatly enhanced DM-catalyzed peptide binding to DR1 compared to unmodified soluble DM and DR1.
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