Sentence examples for binding residues of the from inspiring English sources

The VTD binding residues of the model peptide were identified using the NMR titration experiments with VTD, including a newly discovered VTD binding residue Leu14 (μ1-L1580 in Nav1.4), which has not been reported by point mutation studies.

We interpret additional density close to the non-scissile phosphodiester linking −1 and −2 nucleotides as a Mg2+ ion, consistent with its complexation by Asp 506 and Asp 508, two conserved metal binding residues of the TOPRIM domain [4].

The proposed essential binding residues of the three receptors are presented in Figure  8.

Clustering analysis on putative peptide binding residues of the DAB alleles indicated four functional supertypes, all of which were represented in 4 of 5 populations, albeit at different frequencies.

As previously shown, 22 Myrcludex B-derived peptides specifically enrich in the liver of WT mice, while mutations in the essential receptor binding residues of the peptide lead to a loss of hepatocyte binding.

All these missense mutations in the Zn2+-binding residues of the C3HC4 RING domain have previously been experimentally shown to abolish dimerization of BRCA1 with the BARD1 protein, resulting in loss of ubiquitin protein ligase activity and causing γ-radiation hypersensitivity [ 19, 20].

A comparison of the phosphate-binding residues of the canonical MDD from S. epidermidis to the same positions in R. castenholzii MPD reveals that the R. castenholzii MPD lacks several conserved hydrogen bonding interactions associated with recognition of the terminal phosphate on the diphosphate moiety of MVAPP (5).

The functionally important sites were determined by the mapping of ligand binding residues on the structural alignment of the available structural members.

In red are the concave antigen binding residues of VLR and the complementarity determining regions (CDRs) of Ig.

Bevacizumab is a humanized anti-VEGF monoclonal antibody generated by engineering the VEGF binding residues of a murine neutralizing antibody into the framework of the human IgG.

One such approved antibody is bevacizumab, a humanized anti-VEGF monoclonal antibody generated by engineering the VEGF binding residues of a murine neutralizing antibody into the framework of the consensus human immunoglobulin G1 (IG11).