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These models rendered a useful approximation for binding requirements in the BBB-choline transporter and, until such time as the cloned transporter becomes available, may have significant utility in developing a predictive model for the rational design of drugs targeted to the brain.
Information obtained from this study is useful to determine the binding requirements in BBB-ChT, and until such time as its crystal structure becomes available, it may have significant utility in elaborating a highly predictive model for the rational design of drug-like compounds targeted to the brain.
Knowledge gained from this study is useful to better understand the binding requirements in BBB-ChT, and until such time as its crystal structure becomes available, it may have significant utility in developing a highly predictive model for the rational design of drug-like compounds targeted to the brain.
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In passing, it is interesting to check that "well-behavingness" is a binding requirement in the sense that, without it, we could not find a solution to Problem 2 that is not well-behaved but satisfies conditions (11)–(12) in the Theorem.
Thus, the difference in binding requirements for the FR1c-AP probe and exogenous FGF2 is 6-O-sulphate on glucosamine; by comparing the distribution of the two probes we can examine the distribution of 6-O-sulphate 6-O-sulphate 6-O-sulphate
We chose to contribute to this effort by investigating the effects of the berenil on yeast gene expression, enabling an examination of its in vivo sequence binding requirements.
Thus, the Paris pact has built in a series of legally binding requirements that countries ratchet up the stringency of their climate change policies in the future.
"This memorandum does not impose legally binding requirements and will not be implemented as binding in practice.
Indeed, our in vitro analyses of the binding requirements using immobilized templates confirmed that methylation of cytosine residues within the IGF2BP1 sequence does not affect CTCF binding.
Some of these have been in the absence of accessory proteins, and few have used conditions in which DNA-binding requirements mimic in vivo loading onto chromosomes.
It would also create binding requirements for states to review all cross-border arms contracts to ensure arms will not be used in human rights abuses, terrorism or violations of humanitarian law.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com