These models rendered a useful approximation for binding requirements in the BBB-choline transporter and, until such time as the cloned transporter becomes available, may have significant utility in developing a predictive model for the rational design of drugs targeted to the brain.
Knowledge gained from this study is useful to better understand the binding requirements in BBB-ChT, and until such time as its crystal structure becomes available, it may have significant utility in developing a highly predictive model for the rational design of drug-like compounds targeted to the brain.
Information obtained from this study is useful to determine the binding requirements in BBB-ChT, and until such time as its crystal structure becomes available, it may have significant utility in elaborating a highly predictive model for the rational design of drug-like compounds targeted to the brain.
Thus, the difference in binding requirements for the FR1c-AP probe and exogenous FGF2 is 6-O-sulphate on glucosamine; by comparing the distribution of the two probes we can examine the distribution of 6-O-sulphate 6-O-sulphate 6-O-sulphate
This shows a dissociation between BLyS binding and survival signaling which may be the result of a species difference in the binding requirement for activation of BR3/TACI receptors on human B cells.
Many rich countries now want to sign up to a weak agreement, one with pledges to achieve the targets but no legally-binding requirement, though the EU says it is arguing for legally-binding mitigation targets.
The 2percentt standard is just a guideline, not a legally binding requirement.
Thus, the Paris pact has built in a series of legally binding requirements that countries ratchet up the stringency of their climate change policies in the future.
MEPs reiterated their previous calls "for a 40% energy efficiency target for 2030", considering that "binding requirements are vital in order to achieve a maximum degree of ambition and effort" from the member states.
Indeed, our in vitro analyses of the binding requirements using immobilized templates confirmed that methylation of cytosine residues within the IGF2BP1 sequence does not affect CTCF binding.
