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Whether L-plastin phosphorylation contributes to such a conformational change enabling efficient F-actin binding remains to be investigated.
Only one additional lysine (K229) was observed in the α-enolase from SV41 (Fig. 4A) and its role in plasminogen binding remains to be tested.
Whether this is just a result of commonalities between these glial subtypes that allow for ShH10 permissivity in both or whether infection of one type may facilitate adjacent infection of the other through localized binding remains to be analyzed.
A specific site on AP2 for BST2 binding remains to be clearly elucidated.
The molecular basis for the tissue-specificity of Twist1 binding remains to be determined.
Note that ARID1B (and its paralog ARID1A) are large proteins with multiple putative NPFs, whose binding remains to be tested.
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The biological significance of the identified STAT6 binding sites and further analysis of the binding kinetics remains to be addressed in further studies.
Whether the ability of K11-polyUb linkages to stabilize proteins is due to the topology of the chains, which may prevent the I44 Ub-binding surface from being exposed, or recognition of K11 linkages by as yet unknown K11-selective binding proteins remains to be determined.
Though the functionality of the identified YY1 binding motifs remains to be demonstrated in vivo, it is plausible that some functional constraints serve to maintain the YY1 binding motifs within the protein-coding regions of the OLFR genes.
By contrast, in the third PTPN3 mutant strain, although the nature of the genetic mutation precludes expression of catalytically-active PTPN3 protein, whether or not these mice express truncated forms of PTPN3 that contain only modular binding domains remains to be established.
Moreover, the function of several SLP65 binding partners remains to be elucidated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com