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Molecular docking and MD simulation explored the binding relationship of the ligand and the receptor protein.
Furthermore, we employed molecular docking and re-docking simulation explored the binding relationship of the ligand and the receptor protein in detail.
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Analysis of the structure binding relationships of the series of ESG analogues (4 12) reveals that GSH adducts formed with either rigid (4 9) or flexible electrophiles result in compounds that bind with similar affinity to Kef (for example, compounds 6 and 12).
Two previous papers [ 6, 21] used a statistical error model to assign a p-value of the binding relationship of a TF-promoter pair.
The docking analyses further elucidated the binding relationship of YZG-331 and P-gp.
If p > 0.01, the binding relationship of a TF-promoter pair is of low confidence and cannot be confirmed by promoter-specific PCR most of the time.
They found that if p ≤ 0.001, the binding relationship of a TF-promoter pair is of high confidence and can usually be confirmed by promoter-specific PCR.
However, if 0.001 < p ≤ 0.01, the binding relationship of a TF-promoter pair is ambiguous and can be confirmed by promoter-specific PCR in some cases but not in the other cases.
Such study of the structure-binding relationship of noncovalent protein complexes would help for the drug screening and de novo therapeutic agent design.
Then, the gateway keeps track of this binding relationship between the content/host name and locator locally.
(1) How to make involved consumers or intermediate routers be aware of the binding relationship between the content name and its locator?
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