For example, as shown ChIP-seq in T47d (steroid hormone treated) can more accurately capture TF-gene binding relations in breast cancer than ChIP-seq in Ecc1 cell lines.
An integrated, semantic processor called SemRep identifies many argument-binding relations in text, assisting the summarization phase to accommodate several point-of-view refinements.
Briefly, networks were built by connecting entities with binding relations stored in the ResNet 6 mammal database.
As a result, we compiled a Core map containing 50 proteins (tubulins and generally accepted MAPs and motors) in direct binding relations, previously observed either in somatic cells or in oocytes (Figure S4).
Relations in the world are different.
For example, as noted in our example above, our water molecule W comprises two further facts in which two hydrogen atoms h1 and h2 both stand in the covalent binding relation with an oxygen atom o.
However, when S2-bound DA triggers the formation of the channel, part of this aromatic cluster (F691.35, F761.42 and F3326.65) becomes more solvated (Figure S2 in File S1), supporting the relation between substrate binding in the S2 site and the opening of the intracellular pathway for the penetration of water and the downward movement of the substrate from the S1 site.
We followed up these findings and investigated how VDR binding is involved in the relation between MS regions and chromatin states.
Interestingly, when observing the binding activity in relation to the position of such epitopes in the respective oligopeptides, localization at the COOH-terminus appeared to negatively influence the binding.
In the light of extensive regulation of non-coding RNAs by hypoxia, we reanalysed the distribution of HIF-binding in relation to the location of all transcripts.
