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These binding regions were selected based on ChIP q-PCR validation and proximity to the TSS (Figure 6 A, B).
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Ten potential VDR binding sites located within conserved regions were selected for further testing within the following gene promoters: SEMA3B, CD14, P2RY2, AKAP12, SERPINB1, HBEGF, TXNRD1, CYP26B1, MTSS1 and LOX.
The resulting chromosomal regions were selected for containing at least one LXR binding location within the high stringency set of peaks resulting in 112 separate regions.
These regions were selected as they have shown different AV-45 binding in studies comparing AD patients to control subjects [9 11, 36].
ChIP-enriched regions were selected as being co-associated when a LysM binding region overlapped at least partially with an extended Ss-LrpB ChIP-enriched region.
These regions were selected as they have shown different AV-45 binding in studies comparing AD patients to CN subjects [ 8, 9, 12, 16, 23].
The conserved regions were selected as PCR primer target regions.
Three regions were selected.
Three health regions were selected purposively.
Consequently, six candidate CNV regions were selected.
Consequently, if σ70-binding site avoidance in nonregulatory regions is selected for in order to increase the speed of transcription, the degree of under-representation of these sites in a genome should respond to selection for high growth rate and vary in a manner that correlates with translational optimization.
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