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There were 1,075 human ES SOX2 binding regions that could be annotated with nearby genes.
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This indicates that cells undergoing apoptosis expose CL on their surface in segregated membrane regions that could enhance the binding of circulating autoantibodies.
We predict regions that could contain epitope-binding sites, which might be good vaccine targets.
With this additional stringency for peak calling, it could be that the negative regions as defined by this meta approach harbor enriched regions that could possibly represent true binding sites of lesser affinity to the TF.
The 7SK conservation study identified three regions that could form alternative pairings with the M2 stem [62], therefore, a rearrangement in this region could act as a trigger by disrupting the structure at the base of the large stem loop to which HEXIM1 binds leading to a conformational change of the HEXIM1 binding region.
We were curious whether known TFs could bind to the SOX2 binding regions that we identified and act as SOX2 cooperators for the regulation of gene expression.
We were curious whether other known TFs could be bind to the AR binding regions that we identified and act as AR cooperators for regulation of gene expression.
Our method identifies cis-acting elements in the 3'-untranslated region that could represent either miRNA binding sites or protein binding sites.
It is interesting that there is an inverted repeat motif at the 3′ end of the duplicated region that could be a binding site for an unknown protein factor.
The rationale for providing the cancer polymorphisms information comes from the observation that several 14-3-3 14-3-3 14-3-3ns contain polymorphisms that could in principle interfere with the binding to 14-3-3 (Supplementaregionsre S1).
Leapfrog was able to locate a previously unrecognized binding pocket that could accommodate these otherwise anomalous regions of structure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com