Sentence examples for binding regions that are from inspiring English sources
In such cases, the proteins typically have (nucleic binding) regions that are somewhat disordered and also (catalytic) regions that are highly ordered respectively.
In humans, CBP/p300 binding regions that are outside of genes often overlap with H3K4me1 and are a signature of transcriptional enhancers [ 17].
These analyses produced datasets containing binding regions that are unique to a specific tissue type or shared among multiple tissue types.
SPAM1 has hyaluronic acid and zona pellucida binding regions that are distinct from its catalytic domain [ 13, 14] and is also involved in an intracellular signalling pathway in sperm cells upon binding to the zona pellucida [ 4, 15, 16].
Summary: ANCHOR is a web-based implementation of an original method that takes a single amino acid sequence as an input and predicts protein binding regions that are disordered in isolation but can undergo disorder-to-order transition upon binding.
In order to increase support for the computationally found binding sites, we performed cross-species comparison and indicated promoter binding regions that were conserved.
Primers designed for synARA clones included binding regions that were based on a single I1 site, or combinations of I1I1 and I1I2 sites with and without degenerate bases (Table 1).
Odom and colleagues have previously shown that the transcription factor binding regions that were retained between multiple species had higher sequence constraint than species specific binding regions [ 24], however the interdependence between conservation of the region around the bound site and the retention of the consensus site was not addressed.
This unique loss-of-function mutant retains only nuclear functions and sits in a pocket, outside ATP and substrate binding region, that is suited for designing allosteric inhibitors of IGF1R.
This design was chosen to preserve the Wnt-ligand binding region that is attributed to the CRD, a characteristic feature of Frizzled receptors [16].
