Notably, according to their findings, the C-terminus of Axin forms a "closed" conformation through an intramolecular interaction with the middle β-catenin binding region rather than the N-terminal region as we found.
However, all individual ChIP-Seq datasets are treated independently, thus making it difficult to infer whether two overrepresented transcription factors work combinatorially (e.g. whether they show statistically significant co-occupancy of the same regulatory regions), rather than binding to overlapping sets of gene loci, but using distinct cis-regulatory regions.
The authors suggested that this observation could be explained by the existence of another protein that co-binds with CEH-14 to the highly-occupied target regions rather than CEH-14 binding directly [ 20].
Amisulpride has a low occurrence of EPS because of its preferential binding to dopamine receptors in extrastriatal regions rather than in the striatum.
It offers whole-genome coverage, but has poor resolution since methylation is detected at regions rather than individual residues, and hybridization to the antibody or methyl-binding protein is not necessarily linear to percent methylation.
Nevertheless, the best-studied regulatory SNPs in TBP-binding sites of human promoters seem to have a lot in common with the SNPs in protein-coding regions rather than with the remaining regulatory SNPs.
First, we find vessel regions, rather than simply vessel paths.
Line scans show that H3K79me2 foci are preferentially associated with euchromatic regions rather than heterochromatic regions.
In this study, the EMSA results reinstated that a binding motif in the promoter region rather than expression differences of target genes appears to be more crucial for binding.
Notably, the binding sites identified predominately lie in the mature 18S rRNA region, rather than in the transcribed spacers, and are far more common over evolutionarily conserved regions than over the eukaryotic-specific insertion elements.
