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The peptide binding regions of these genes are classical examples of balancing selection [ 37].
A significant portion of the genomic binding regions of these TFs contain more than one binding sites, which explains why the forward tag stacks overlap with the reverse tag stacks.
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Black lines denote the DNA binding regions of the control ZFN protein.
The binding region of these mAbs has been localised to a conserved region of the HA stem domain.
The extracellular binding region of these two receptors for EGFR and HER2 are proteolytically released from the cell surface upon receptor activation and can be detected in patients' serum.
As the binding mode of CMPD1 and CMPD2 in EphB4 has previously been determined by X-ray crystallography [ 34, 35], we were able to use these structures together with a sequence alignment (Supplementary Figure S1), to look for differences between EphB3 and EphB4 in the binding region of these two compounds.
The extracellular, ligand-binding regions of these receptors each have a defining arrangement of two tandem immunoglobulin-related domains and two fibronectin type III repeats.
The high variability of the peptide-binding regions of these two genes ensures that hosts can recognize a broad spectrum of pathogens, and these regions are consequently subject to strong positive selection.
The mutation leads to a AA change in the nucleotide binding region of the HELICc-Domain.
DNA is negatively charged, and the DNA binding region of the protein is often positively charged.
As expected, the FHTA peptide bound in the FXXA binding region of the protein.
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