There are two major functional domains, the N-terminal domain (NT), contains the major receptor binding region, the C-terminal domain (CT), contains the lipid binding region, which is also thought to bind Aβ [9], [10].
Experimental studies on apoE are focused on its receptor binding region, which is located between residues 130 150 and is critical for its biological activity.
The signal molecule binding region, which is located in the N-terminal portion of the protein and a helix-turn-helix motif (HTH) located in the C-terminal, which is responsible for the protein binding to the target promoters [13] [15].
It consists of an extracellular ligand binding region, which is connected to the cytosolic region through a hydrophobic transmembrane domain.
The docking site of MX2 was identified by the nucleotide binding region which was recorded as the relation with GTP function.
Interestingly, A. niger P43 has GST C-terminal domain at the N-terminal of the tRNA binding region, which is different from the human counterpart.
Immediately adjacent to the N-terminal J-domain of Class I J-proteins is a glycine/phenylalanine (GF -rich linker reGF -richlinker by the client pregion binding region, which is composed ofollowedrrel topology domains, CTD1 and CTD2.
The p. K23N (c.69 G->T) mutation in the HSF4 gene detected in our present study was located within the highly conserved HSF DNA binding region, which is shared across heat shock transcription factors (HSFs) and between species, as shown by multiple-sequence alignment.
Overall, up to 61.3% of EIs overlap with CTCF binding regions, which are 8.2-fold enriched compared with the random pattern (P < 10-3, Table 2).
