The "nucleotide-P binding" region is associated to the highest ribosome occupancy.
The mutation F317L located in the adenosine triphosphate binding region is associated with resistance to dasatinib, and these patients may respond positively to nilotinib.
Thus, we have defined two types of Otx2 binding region depending on whether Oct4 cobinding occurs and these two different categories of binding region are associated with genes involved in different biological processes.
Moreover, Twist1 binding regions are associated with several Wnt pathway genes and pathway components.
Previous studies on these ChIP-seq data have shown that many detected binding regions are associated known canonical motifs of these factors [ 6, 20, 21, 28, 31].
Gene ontology analysis revealed that a large proportion of the Otx2 binding regions are associated with genes encoding transcriptional regulators that form a highly interconnected network.
Likewise, the limb bud-specific binding regions were associated with the genes son of sevenless homolog 2 (Sos2), transmembrane protein 18 (tmem18), and abhydrolase domain containing 6 (andd6), and were bound by Twist1 in limb buds, but not in ECCs or PNST cells.
They noted that the top 1% of MEIS-binding regions were associated with genes involved in skeletal muscle development (see Figure 5F in Amin et al., 2015).
GlnR-binding regions were associated with genes involved in primary nitrogen metabolism, secondary metabolism, the synthesis of catabolic enzymes and a number of transport-related functions.
In line with this suggestion, conserved tandem repeats in the DMRs of Peg3 and at the Gnas locus contain YY1 binding sites [ 22] and also the Prader-Willi/Angelman Syndrome regisn is associated with YY1 binding sites [ 23].
