Therefore, we modified the program such that it allows "binding regions" rather than narrow peaks to be identified; see Supplementary Information S1 and Figure S1 for more details about Sole-searchv2.
In this study, the EMSA results reinstated that a binding motif in the promoter region rather than expression differences of target genes appears to be more crucial for binding.
Notably, the binding sites identified predominately lie in the mature 18S rRNA region, rather than in the transcribed spacers, and are far more common over evolutionarily conserved regions than over the eukaryotic-specific insertion elements.
As reported, we found that all the Sir proteins are highly enriched at heterochromatin region rather than euchromatin region in wild-type cells, while sir3Δ completely abolishes the Sir proteins binding over the heterochromatin region.
In fact, Fu and Li's D was weakly positive upstream of the coding region rather than negative, contrary to what might be expected based on its putative role in binding the host ribosome [ 35].
We categorized jurisdictions based on their geographical region rather than their WHO region.
However, all individual ChIP-Seq datasets are treated independently, thus making it difficult to infer whether two overrepresented transcription factors work combinatorially (e.g. whether they show statistically significant co-occupancy of the same regulatory regions), rather than binding to overlapping sets of gene loci, but using distinct cis-regulatory regions.
The authors suggested that this observation could be explained by the existence of another protein that co-binds with CEH-14 to the highly-occupied target regions rather than CEH-14 binding directly [ 20].
Amisulpride has a low occurrence of EPS because of its preferential binding to dopamine receptors in extrastriatal regions rather than in the striatum.
Our limited knowledge of this region of the channel (structures of potassium channel are by necessity different in this region) precludes identifying the source of increased helicity observed upon TTX binding in the present study, but it is likely to involve the extracellular regions rather than the transmembrane domains.
