Sentence examples for binding region of the from inspiring English sources
In yeast, WWDYG likely forms the active site of the enzyme or the binding region of the N-glycosylation recognition site (Yan and Lennarz 2002).
The optimized target energy value of molecular docking is obtained by calculating the interaction between the ligands and the binding region of the receptors.
Their team cloned the genes for fragments of binding region of the mouse anthrax antibody in a virus and improved their affinity for PA by repeatedly generating variants and picking out the ones that bound PA best.
Here we report a study of the backbone dynamics by 15N-spin relaxation on the CaM dimer in complex with a dimeric peptide that mimics the CaM binding region of the bHLH transcription factor SEF2-1.
We found four key sites (A: solvent-exposed front pocket, B: hinge region, C: selectivity pocket and D: solvent-exposed phosphate binding region) of the Aurora A kinase contributing towards the binding of these compounds.
Aptamers selected via the Systematic Evolution of Ligands by Exponential Enrichment (SELEX) were structurally modified and truncated to narrow down the binding region of the target, which indicated that loops of the aptamer contributed different functions for different chemical recognition.
Finally, class III RTKIs such as neratinib, covalently bind to cysteine residues within the intracellular ATP-binding region of the receptor (Gotink and Verheul, 2010; Davis et al., 2011).
The adapter consisted of a CEA-specific single-chain antibody fused to the gD-binding region of the gD receptor, herpes virus entry mediator (HVEM).
Here, we report the rational design of Chk2 inhibitors that target the gatekeeper-dependent hydrophobic pocket located behind the adenine-binding region of the ATP-binding site.
This metabolic biotinylation method yielded functional nanobodies with one biotin located at a distant site of the antigen-binding region of the molecule.
Comparative modelling of the 3-D structure of LDGLOI shows that substrate-binding region of the model involves important differences compared to the homologues, such as E. coli, specific to glutathione.
