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Although there is postulation that the specific binding region of such peptides can be further exploited for the development of a biologic drug that is isoform selective [ 123].
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Indeed, we found that the first membrane binding region of Nup53 contains such a cluster.
These high affinity binding residues span different RNA binding regions of AspRS such as anti-codon binding domain, hinge region, catalytic and insertion domains.
The complete explanation and insight of such phenomenon awaits the structure determination of the receptor binding region of apoB-100 in native LDL to an even higher resolution.
Several such analogs, based on modifications of the FRB binding region of rapamycin, have been developed in the last few years [45] [47].
For the highly structured hubs (such as 14-3-3 14-3-3 14-3-3modulin [ 28]), the binding regions of their pandner proteins are intrinsicalmodulinrdered [ 30].
Such differences suggest that substantial divergence may occur in secondary and tertiary structures at the receptor-binding region of these two lion lentiviruses.
A minimal BubR1-binding region of Bub1.
Although there is considerable variation in the motifs that different effectors use to bind Rho GTPases, a number of effectors share consensus binding regions such as the Cdc42/Rac-interactive-binding (CRIB) domain found in Wiskott Aldrich syndrome protein (WASP) and P21-activated kinase (PAK).
Importantly, six evolutionary markers of A/Hawaii/64/2014(H1N1) reside in known antibody-binding regions of HA and NA, suggesting that such vaccine candidates could induce better protective immunity against live viruses than the strains recommended by the WHO.
Thus transcription factor binding regions uncovered in such screens do not necessarily demarcate enhancer elements [42].
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