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ANF-receptor module corresponding to the ligand binding region of several receptors [ 75] was found associated with a trypsin homologue (YP_073997.1) in Symbiobacterium thermophilum [ 5] (Table 3; Additional file 1).
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Because the conformational transition is slow, the binding region of EBs is rather extended, consisting of several hundreds of tubulins and giving rise to the comet-shaped appearance in fluorescence microscopy images.
Several such analogs, based on modifications of the FRB binding region of rapamycin, have been developed in the last few years [45] [47].
We have also studied several binding regions of ligands other than the target region.
To further map the BLM-binding region of PICH, we constructed several Myc-PICH truncation mutants, expressed them in HeLa cells, and tested their interactions with the endogenous BLM.
There are several ways to identify the binding regions of transcription factors to DNA by using an atomic force microscope (AFM).
This would be much shorter than the EB binding region, which consists of several hundreds of binding sites (Bieling et al., 2007, 2008; Dixit et al., 2009).
TCF/Lef and VDR variant consensus motifs were defined by comparing the natural binding sites in the promoter region of several target genes (Table S2).
A minimal BubR1-binding region of Bub1.
Moreover, proteasome inhibition with bortezomib alters the binding of other transcription factors to the promoter region of several molecular effectors, thus modulating their expression levels [ 149].
Products are not consumed when they bind; thus the product from a single gene is sufficient for binding the regulatory regions of several genes (effectively, we ignore quantities of gene products).
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