Sentence examples for binding region for small from inspiring English sources

Many nuclear import pathways are not valid drug targets, due to lack of specificity in NLS-import factor interactions; however, the huntingtin NLS has a unique structured IVS that could be exploited as a binding region for small molecules.

Interestingly, neighbourhood of binding region for 407882 has been already indicated by Mornon as potential target for pharmacological intervention by small molecule (Mornon et al, 2008).

We used the following procedure for identification of binding regions for factors that identify broad regions.

The information gained about complementary properties of the allosteric binding region and the small molecule ligands are the basis for the optimization of high-affinity antagonists for the TSHR for treatment of GO or constitutive activation by pathogenic mutations.

An inter-protomer pocket within the hexamer configuration of the CA, which is a binding site for key host dependency factors, is an especially appealing region for small molecule targeting.

It has a slightly different structure, composed of only heavy chains which makes the binding region smaller and easier to work with.

This informs that such immune-related binding regions are small than average.

The three-dimensional structure of Rsd in complex with σ70 region 4 reveals that the sigma-binding surface is connected to exposed cavities, which might act as binding pockets for small regulatory molecules.

Moreover, compared with the SL1067 binding region of IL-1α, IL-1β has a much smaller hydrophobic area and different surface topology (Supplementary Fig. 6a), making it an unsuitable target for SL1067.

However, smaller peptides derived from the receptor binding region of apoE have been developed that mimic the functional anti-inflammatory and neuroprotective effects of the intact apoE protein.

Black underlines indicate the direct binding region.