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The two peak pattern of Est2p telomere binding reflects two independent pathways of telomerase recruitment.
Thus, retrospective action binding reflects a context-dependent, model-based phenomenon.
Recent evidence supports the view that temporal binding reflects (voluntary) temporal control rather than action-independent temporal predictability (Desantis, Hughes, & Waszak, 2012; Haggard et al., 2002).
Since all other ARs which could have interfered were already blocked, this further reduction of radioligand binding reflects selective A3R competition of the radioligand, and therefore the presence of the A3R protein in the tissues of interest (Table 2).
Binding is not necessarily highly selective, as in the case of the transcriptional repressor CoR or NotchIC binding to CSL (43), where binding reflects cellular concentrations; at the same time, cellular events reflect allosteric effects that amplify minor conformational changes, thus spelling higher selectivity.
The increased binding reflects functional changes within the OR system, in response to the visual deprivation, and demonstrates adaptive mechanisms that may take place in neurodegenerative disorders, e.g. non-hypothesized increased binding in the thalamus as well as cingulate and frontal cortices in patients with HD (Weeks et al., 1997).
Similar(54)
We suggest that the structural changes in β-lactam inhibitor binding reflect the state of the enzyme at an initial stage of substrate binding to the active site.
In this respect, preclinical experiments that use more selective compounds should be performed to investigate whether caffeine's effects on [11C]raclopride binding reflect changes in the expression or in the affinity of D2/D3R and whether these effects reflect caffeine's antagonism at A2AR.
Measurements of rapid kinetics of oxygen dissociation and carbon monoxide binding reflect the ATP sensitivity observed in equilibrium experiments.
As the specific binding to active targets may have a profound impact on the overall pharmacological activity [32], the effects of a variety pattern of protein binding reflected in the uptake profiles by cell membrane on therapeutic efficacy of drugs could be adapted as a primary screening means.
This binding reflected low avidity interaction(s), ∼1 log lower avidity than did 2F5-gp41 MPER interactions (Kd values were 275.5 and 10 nM, respectively), as calculated by surface plasmon resonance analysis (Table S3).
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