Sentence examples for binding reasons from inspiring English sources

Law ultimately rests on custom: customs about who shall have the authority to decide disputes, what they shall treat as binding reasons for decision, i.e. as sources of law, and how customs may be changed.

The advantages of small organic molecules are the preorganization of hydrogen bond donors and acceptors that favour binding for reasons of entropy.

Given its influence on ligand binding, we reasoned that Trx1 might interfere with CD30-mediated signaling.

Because TRADD and RIP1 compete for TNFR1 binding, we reasoned that TRADD contributes to this switch to apoptosis upon RIP1 loss.

Because mutants A1, B2 and D2 contained only single or double mutations that readily displayed high-affinity [H]granisetron binding, we reasoned that these subtle changes alone are sufficient to mimic the 5-HT3R-binding site.

DOI: http://dx.doi.org/10.7554/eLife.03772.028 Since the activity of phosphorylated IGF1R-fl is high and unaffected by ligand binding, we reasoned that autophosphorylation must be the step controlled by ligand-dependent allostery.

Nativity is the binding theme, for reasons that would be obvious, even if the artists didn't strive to make it so.

28 In the present study we developed dopamine D2 receptor models to gain a better insight into agonist binding and the reasons behind the selectivity between full agonists and structurally similar inactive compounds.

In the optimized γGlu-Ca2+ geometry (Supplementary Fig. 1C), the T-shaped structure is retained and the ion is chelated by three O atoms of the two negatively charged carboxylates; the average Ca O distance is 2.3 Å; the fourth O atom is hydrogen bonded to the close amide group and cannot be involved in calcium binding for steric reasons.

In brain receptor PET studies the most effective simplification was achieved by combining the compartment of free radioligand with the compartment of nonspecific binding for multiple reasons; the two compartments are located on the tissue side of the blood brain barrier, the two compartments are either at or in rapid equilibrium, or the two components have similar turnover rates.

This is not to say that one obeys only in treating the authority's say-so as an indefeasible reason for action; but one must treat as a binding content-independent reason.