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We found that although none of these inhibitors altered the structure of CETP or the conformation of CETP-lipoprotein binary complexes, all inhibitors, especially Torcetrapib and Anacetrapib, increased the binding ratios of the binary complexes (e.g., HDL-CETP and LDL-CETP) and decreased the binding ratios of the HDL-CETP-LDL ternary complexes.
When the binding ratios of the reference ligand and the candidate ligand are below 10%, ABA/ RRA × CR) and ABX/ RRx/ CR) are negligible in comparison to ATA and ATX[ 30], respectively, and thus Eq. (6) applies.
In the presence of 40 μM biotin in a competitive binding system containing the PMFS of Mixture A via SPSAG, the binding ratios of the five biotin derivatives were all reduced by over 35%.
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The binding ratio of the RbQ Hg2+ complex was found to be 1 1 according to Job plot experiment, and the limit of detection was 1.05×10−7 M.
The binding ratio of the tweezers and cephradine is determined to be 1 1 according to ESI-MS analysis, which is further supported by the Job plot.
The binding ratio of the probe QP and Cu2 + ion was determined to be 1 1 through fluorescence titration, Job's plot and ESI-MS.
The mean hypothalamic SERT binding ratio of the present study appeared to be lower than previously reported in the diencephalon [23], possibly related to a more precise delineation of the target area in the present study and to age differences.
The binding ratio of the L Zn2+ complex was 1 1 confirmed by the 1 HNMR, mass-spectral analysis and Job plot, and the detection limit for Zn2+ was as low as 5.2 × 10−7 M.
The binding ratio of the radiolabelled I-PAG to the antiserum was considered as 100% in the zero standard (B0) assay tube.
After Lowess normalization the binding ratio of the duplicates were averaged and a Z score value was calculated for each spot.
The binding of any genomic region that is covered by a probe is represented by the log2 binding ratio of the probe; the binding of a region that is not covered by a probe is zero.
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