Specific [123I]β-CIT binding ratios in striatum, caudate nucleus, putamen, and midbrain were calculated using the formula: (mean binding in ROI-mean occipital binding) / mean occipital binding.
Homologues with a shorter fluoroalkyl chain consistently showed greater D2/3R-specific-to-total binding ratios in the striatum than those with longer chains.
This paper provides an extension of a procedure for calculating counterion binding ratios in a polyelectrolyte solution based on the Poisson-Boltzmann formulation of territorial counterion binding to include the presence of excess salt of the counterion.
We did not find altered specific-to-nonspecific [123I]FP-CIT binding ratios in patients treated for a large sellar tumor giving rise to visual field defects, although a number of methodological issues preclude a definitive conclusion.
For algorithms taking SBRs as the input, pre-processing involved normalising the binding ratios in each putamen and caudate such that the mean value was zero with a standard deviation of 1.
In our previous pharmacokinetics studies, ZMYL produced a potential drug-herbs interaction on pharmacokinetic parameters of CDDP calculating from the total and free Pt concentration and Pt plasma protein binding ratios in the early stages in normal rats [ 18].
Overall, the HP1 binding ratios in XSyx4-CG3603 are somewhat lower than those in the pericentric heterochromatic regions of chr 4 and chr 2R (cf. Figure 1D and data not shown).
The Pt plasma protein binding ratios in the early stages (at 0.17, 0.33, 0.5, 1 h after dosing of CDDP) were boosted significantly by combination with ZMYL in normal rats [ 18], but no difference was discovered in SK-OV-3-bearing nude mice model.
In our previous pharmacokinetics studies in normal rats [ 18], ZMYL could produce a potential pharmacokinetics drug-herbs interaction on pharmacokinetic parameters of CDDP and plasma protein binding ratios in the early dosing stages (at 0.17, 0.33, 0.5, 1 h after dosing of CDDP).
Of note, the binding ratio in the group of control subjects, as well as in the HI group, is significantly above 0 (one-sample t test: t = 3.09, p = 0.027), and the variability in binding ratio is in line with that reported by Kupers et al. [21].
