Sentence examples for binding quantity in the from inspiring English sources

Because no replicates were available for the test data, a Poisson mixture model was used to identify estrogen-induced differences in Pol II binding quantity in the two cell lines.

This figure demonstrates a clear trend that with the increase of the number of Pol II binding quantity in the gene transcript region, a less relative change is required for a gene to be considered as major change (red dots, Z i ≥ 0.9), or minor change (green dots, 0.1 ≤ Z i < 0.9), where Z i is a posterior probability that the Pol II binding quantity changed after E2 treatment.

Overall, in wild type MCF7 cells, Pol II binding quantities in the gene transcript region of 9.9% and 9.7% of the genes were classified as major (Z ≥ 0.9) and minor (0.1 ≤ Z < 0.9) changes, respectively (Fig. 5A).

As the Pol II binding quantity in each gene transcript region reflects the expression level of the corresponding gene, we analyzed whole genome Pol II binding distributions for the four breast cancer cell samples.

We tested our model on the Pol II binding quantity in MCF7 and OHT-MCF7 breast cancer cell lines (+/- E2 treatment) derived from the use of ChIP-seq technology.

We report a Poisson mixture model to identify estrogen-induced changes in Pol II binding quantity in wild type MCF7 cells and OHT-resistant MCF7 cells.

In this model, small signals require large changes in binding quantity to reach the same level of significance.

Therefore, the joint distribution of Pol II binding quantity is modeled by a mixture of uniform binding events (p = 0) and differential binding events (p = 1).

A mixture model is proposed to estimate the posterior probability of differential Pol II binding quantity.

In all four samples, the expected promoter decay factors Kp were larger than the expected transcription decay factor Kt, indicating that RPol II binding quantities reached steady state levels more rapidly in the transcript region (downstream of the TSS) than in the promoter (upstream) region.

However, the slopes of the regression lines are always above zero indicating that the supernatants contain a small quantity of dispersed binding capacity in the form of a small fraction of damaged ghosts and/or released protein, which will bind some ligand called dispersed-bound-ligand (DB).